Clinical resources

Whether you want more information to aid your management of MPS VI or tools to help your patients, we have many valuable resources to share.

Resources for healthcare professionals

BioMarin is pleased to provide the following clinical reprints, brochures, and practice tools to aid you in managing MPS VI. Simply click on the icon or link to access the desired resource.

Clinical studies

MPS VI clinical surveillance program

BioMarin encourages participation in data collection for the MPS VI Clinical Surveillance Program (CSP). The MPS VI CSP is an ongoing observational database tracking the medical history and outcomes of people with MPS VI.

Advancing MPS VI treatment and research

  • Provides a resource to physicians and patients for optimizing patient care
  • Evaluates long-term safety and efficacy of NAGLAZYME® (galsulfase)
  • Establishes the first comprehensive resource for understanding the variability and progression of MPS VI, as well as the long-term safety and efficacy of the only enzyme replacement therapy indicated for its treatment
  • Collects data from multiple centers around the world to compile in an observational database of longitudinal data, available to participating physicians

Optimizing patient care

  • Consolidates data to develop new patient-monitoring standards
  • Reports patient outcomes
  • Provides new understanding for optimizing patient care
  • Recommended assessments reflect a high standard of patient care based on feedback from geneticists who have treated MPS VI patients

Easy participation for both physician and patient

  • Participation in the CSP is voluntary
  • No experimental treatments or assessments
  • The only requirements to enroll a patient are a confirmed diagnosis of MPS VI, appropriate institutional approval, and patient or legal guardian consent

Patient/caregiver resources

To help patients and families manage MPS VI, BioMarin offers several valuable brochures and practical tools. Simply click on the link to access the desired resource.

Important Safety Information

Indication

NAGLAZYME® (galsulfase) is indicated for patients with Mucopolysaccharidosis VI (MPS VI; Maroteaux-Lamy Syndrome). NAGLAZYME has been shown to improve walking and stair-climbing capacity.

Important Safety Information

Life-threatening anaphylactic reactions and severe allergic reactions have been observed in some patients during NAGLAZYME (galsulfase) infusions and up to 24 hours after infusion. If these reactions occur, immediate discontinuation of NAGLAZYME is recommended and appropriate medical treatment should be initiated, which may include resuscitation, epinephrine, administering additional antihistamines, antipyretics or corticosteroids. In patients who have experienced anaphylaxis or other severe allergic reactions during infusion with NAGLAZYME, caution should be exercised upon rechallenge; appropriately trained personnel and equipment for emergency resuscitation (including epinephrine) should be available during infusions.

As with other enzyme replacement therapies, immune-mediated reactions, including membranous glomerulonephritis have been observed. In clinical trials, nearly all patients developed antibodies as a result of treatment with NAGLAZYME; however, the analysis revealed no consistent predictive relationship between total antibody titer, neutralizing or IgE antibodies, and infusion-associated reactions, urinary glycosaminoglycan (GAG) levels, or endurance measures.

Caution should be exercised when administering NAGLAZYME to patients susceptible to fluid volume overload because congestive heart failure may result. Consider a decreased total infusion volume and infusion rate when administering NAGLAZYME to these patients.

Consideration to delay NAGLAZYME infusion should be given when treating patients who present with an acute febrile or respiratory illness. Sleep apnea is common in MPS VI patients and antihistamine pretreatment may increase the risk of apneic episodes. Evaluation of airway patency should be considered prior to the initiation of treatment. Patients using supplemental oxygen or continuous positive airway pressure (CPAP) during sleep should have these treatments readily available during infusion in the event of an infusion reaction, or extreme drowsiness/sleep induced by antihistamine use.

Pretreatment with antihistamines with or without antipyretics is recommended prior to the start of infusion to reduce the risk of infusion reactions. If infusion reactions occur, decreasing the infusion rate, temporarily stopping the infusion, or administering additional antihistamines and/or antipyretics is recommended.

During infusion, serious adverse reactions included laryngeal edema, apnea, pyrexia, urticaria, respiratory distress, angioedema, and anaphylactoid reaction; severe adverse reactions included urticaria, chest pain, rash, abdominal pain, dyspnea, apnea, laryngeal edema, and conjunctivitis. The most common adverse events (=10%) observed in clinical trials in patients treated with NAGLAZYME were rash, pain, urticaria, pyrexia, pruritus, chills, headache, nausea, vomiting, abdominal pain and dyspnea. The most common adverse reactions requiring interventions are infusion-related reactions.

Spinal/cervical cord compression is a known and serious complication that is expected to occur during the natural course of MPS VI. Signs and symptoms of spinal/cervical cord compression include back pain, paralysis of limbs below the level of compression, and urinary or fecal incontinence. Patients should be evaluated for spinal/cervical cord compression prior to initiation of NAGLAZYME to establish a baseline and risk profile. Patients treated with NAGLAZYME should be regularly monitored for the development or progression of spinal/cervical cord compression and be given appropriate clinical care.

To report SUSPECTED ADVERSE REACTIONS contact BioMarin Pharmaceutical Inc. at 1-866-906-6100, or FDA at 1-800-FDA-1088 or go to www.fda.gov/medwatch.

Please see full Prescribing Information.