{"id":41,"date":"2024-11-18T12:21:50","date_gmt":"2024-11-18T12:21:50","guid":{"rendered":"https:\/\/www.naglazyme.com\/en-us\/?page_id=41"},"modified":"2026-05-14T09:54:13","modified_gmt":"2026-05-14T09:54:13","slug":"benefits-of-naglazyme","status":"publish","type":"page","link":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/","title":{"rendered":"Benefits of NAGLAZYME"},"content":{"rendered":"<div id=\"acf-block-673c6c493cfc0\" class=\"block wrapped-content block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-673c6c493d17d\" class=\"block-wysiwyg\">\n            <h1>Benefits of NAGLAZYME<sup>\u00ae<\/sup> (galsulfase)<\/h1>\n<h2>In MPS VI, the buildup of GAGs can lead to organs or bodily systems being harmed.<sup>1<\/sup><\/h2>\n<p>Reducing the level of GAGs may help to slow the decline associated with this condition. NAGLAZYME<sup>\u00ae<\/sup> (galsulfase) provides the missing enzyme in MPS VI so that cells can break down and significantly reduce the buildup of GAGs.<sup>2,3<\/sup><\/p>\n<p>If left untreated, individuals with MPS VI can develop severe complications that can lead to physical difficulties, including<sup>4<\/sup>:<\/p>\n<ul>\n<li>Reduced endurance or walking distance<\/li>\n<li>Difficulty breathing<\/li>\n<\/ul>\n<p>Endurance is an important measure in people with MPS VI because it can show how well your heart, lung, and musculoskeletal systems are working together. MPS VI experts recommend using timed walking and stair-climbing tests to assess endurance.<sup>5<\/sup><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-673cb8be7dc33\" class=\"block fact-box block-tight-top\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <div class=\"box-title\"><h2>Interesting Fact\n<\/h2><\/div>\n\t\t\t\t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\t\t\t\t    <h5>Measuring endurance and the level of GAGs in the urine (uGAGs) can help doctors keep track of changes over time and see how well NAGLAZYME is working.<sup>4<\/sup><\/h5>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-673c6c493d1cf\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-673c6c493d1f2\" class=\"block-wysiwyg\">\n            <h2>Quick improvement with NAGLAZYME<\/h2>\n<p>In the 6-month primary study, individuals receiving NAGLAZYME on a weekly basis significantly improved their endurance and reduced the level of uGAGs.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-673c6e39be61a\" class=\"block boxed-content top-border boxed-content-white\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\n<div id=\"acf-block-673c6e39bea4b\" class=\"image-text-block content-align-center\">\n            <div class=\"image-block small\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.naglazyme.com\/en-us\/wp-content\/uploads\/sites\/2\/2024\/11\/quick-endurance.png?v=0.37\" alt=\"\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Improved endurance\n<\/h3>\n                            <p>On average, individuals receiving NAGLAZYME experienced a <strong>23% improvement<\/strong> in walking distance* and a <strong>38% improvement<\/strong> in stair-climbing.<sup>3,4<\/sup><br \/>\n<small>*Results were taken from the 6-minute time point of the 12-minute walk test.<\/small><\/p>\n                    <\/div>\n<\/div>\n\n<div id=\"acf-block-673c6e39beb01\" class=\"image-text-block content-align-center\">\n            <div class=\"image-block small\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.naglazyme.com\/en-us\/wp-content\/uploads\/sites\/2\/2024\/11\/quick-gag.png?v=0.37\" alt=\"\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Reduced uGAGs\n<\/h3>\n                            <p>Regardless of their state of MPS VI progression, patients treated with NAGLAZYME showed an average\u00a0<strong>75% reduction<\/strong> in the level of uGAGs.<sup>4<\/sup><\/p>\n                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-673c6fef255b2\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-673c6fef2571a\" class=\"block-wysiwyg\">\n            <h2>Weekly infusions lead to long-lasting improvement<\/h2>\n<p>According to a 10-year follow up study, we now know the benefits of NAGLAZYME can be maintained over the long-term and are consistent with the results of the primary study. This study examined endurance, lung function, and the level of uGAGs in patients who had been receiving NAGLAZYME for up to 10 years (the average time on NAGLAZYME therapy was 6.8 years).<sup>2<\/sup><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-673c6fef2593e\" class=\"block boxed-content top-border boxed-content-white\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\n<div id=\"acf-block-673c6fef25ccf\" class=\"image-text-block content-align-center\">\n            <div class=\"image-block small\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.naglazyme.com\/en-us\/wp-content\/uploads\/sites\/2\/2024\/11\/weekly-endurance.png?v=0.37\" alt=\"\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Improved endurance\n<\/h3>\n                            <p>Results from the long-term follow-up study demonstrated that individuals who were on NAGLAZYME long-term continued to experience a\u00a0<strong>21% increase<\/strong>\u00a0in walking distance.<sup>2\u2020<\/sup><br \/>\n<small><sup>\u2020<\/sup>Results from the 6-minute walk test.<\/small><\/p>\n                    <\/div>\n<\/div>\n\n<div id=\"acf-block-673c6fef25d5b\" class=\"image-text-block content-align-center\">\n            <div class=\"image-block small\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.naglazyme.com\/en-us\/wp-content\/uploads\/sites\/2\/2024\/11\/weekly-lungs.png?v=0.37\" alt=\"\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Helped lungs work better\n<\/h3>\n                            <p>Continued treatment with NAGLAZYME has been shown to\u00a0<strong>improve lung function<\/strong> in eligible people with MPS VI, which can make breathing easier.<sup>2<\/sup><\/p>\n                    <\/div>\n<\/div>\n\n<div id=\"acf-block-673c6fef25dfb\" class=\"image-text-block content-align-center\">\n            <div class=\"image-block small\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/www.naglazyme.com\/en-us\/wp-content\/uploads\/sites\/2\/2024\/11\/weekly-gag.png?v=0.37\" alt=\"\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Reduced uGAGs\n<\/h3>\n                            <p>Long-term adherence to NAGLAZYME treatment showed sustained reduction in the level of uGAGs that was <strong>87.9% lower<\/strong> than at baseline.<sup>2<\/sup><\/p>\n                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-69aedcdfc06eb\" class=\"block wrapped-content block-tight-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69aedcdfc0712\" class=\"block-wysiwyg\">\n            <p><strong>If you would like to learn more about NAGLAZYME clinical studies, talk to your doctor or contact\u00a0<a href=\"https:\/\/www.naglazyme.com\/en-us\/contact-biomarin-rareconnections\/\">BioMarin RareConnections\u2122<\/a>.<\/strong><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-691f1f2d5c162\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>References:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>\nSwiedler SJ, Beck M, Bajbouj M, et al. Threshold effect of urinary glycosaminoglycans and the walk test as indicators of disease progression in a survey of subjects with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). <em>Am J Med Genet A.<\/em> 2005;134A(2):144-151.\n\n<\/span><\/li>\n                                                                                                                                                <li><span>Giugliani R, Lampe C, Guffon N, et al. Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome): 10-year follow-up of patients who previously participated in an MPS VI Survey Study. <em>Am J Med Genet A.<\/em> 2014;164A(8):1953-1964.\n<\/span><\/li>\n                                                                                                                                                <li><span>NAGLAZYME [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2024.\n<\/span><\/li>\n                                                                                                                                                <li><span>Harmatz P, Giugliani R, Schwartz IV, et al. Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3 randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine-4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. <em>J Pediatr.<\/em> 2006;148(4):533-539.\n<\/span><\/li>\n                                                                                                                                                <li><span>McDonald A, Steiner R, Kuehl K, Turbeville S. Clinical utility of endurance measures for evaluation of treatment in patients with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). <em>J Pediatr Rehabil Med.<\/em> 2010;3(2):119-127.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"next\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-673c6b0e7d644\" class=\"block-wysiwyg\">\n            <p style=\"text-align: right;font-size: 1.1rem\"><a style=\"text-decoration: none\" href=\"https:\/\/www.naglazyme.com\/en-us\/safety-information\/\"><strong>NEXT PAGE &gt;<\/strong><\/a><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Benefits of NAGLAZYME | Patient<\/title>\n<meta name=\"description\" content=\"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Benefits of NAGLAZYME | Patient\" \/>\n<meta property=\"og:description\" content=\"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin Naglazyme Patient EN-US\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-14T09:54:13+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/benefits-of-naglazyme\\\/\",\"url\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/benefits-of-naglazyme\\\/\",\"name\":\"Benefits of NAGLAZYME | Patient\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/#website\"},\"datePublished\":\"2024-11-18T12:21:50+00:00\",\"dateModified\":\"2026-05-14T09:54:13+00:00\",\"description\":\"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/benefits-of-naglazyme\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/benefits-of-naglazyme\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/benefits-of-naglazyme\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Benefits of NAGLAZYME\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/#website\",\"url\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/\",\"name\":\"BioMarin Naglazyme Patient EN-US\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Benefits of NAGLAZYME | Patient","description":"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/","og_locale":"en_US","og_type":"article","og_title":"Benefits of NAGLAZYME | Patient","og_description":"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.","og_url":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/","og_site_name":"BioMarin Naglazyme Patient EN-US","article_modified_time":"2026-05-14T09:54:13+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/","url":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/","name":"Benefits of NAGLAZYME | Patient","isPartOf":{"@id":"https:\/\/www.naglazyme.com\/en-us\/#website"},"datePublished":"2024-11-18T12:21:50+00:00","dateModified":"2026-05-14T09:54:13+00:00","description":"NAGLAZYME\u00ae (galsulfase) can help reduce the buildup of protein in the cells that causes many symptoms.","breadcrumb":{"@id":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.naglazyme.com\/en-us\/benefits-of-naglazyme\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.naglazyme.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"Benefits of NAGLAZYME"}]},{"@type":"WebSite","@id":"https:\/\/www.naglazyme.com\/en-us\/#website","url":"https:\/\/www.naglazyme.com\/en-us\/","name":"BioMarin Naglazyme Patient EN-US","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.naglazyme.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":68,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":1039,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/41\/revisions\/1039"}],"wp:attachment":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}