{"id":39,"date":"2024-11-18T12:21:19","date_gmt":"2024-11-18T12:21:19","guid":{"rendered":"https:\/\/www.naglazyme.com\/en-us\/?page_id=39"},"modified":"2026-05-18T08:33:42","modified_gmt":"2026-05-18T08:33:42","slug":"how-does-naglazyme-work","status":"publish","type":"page","link":"https:\/\/www.naglazyme.com\/en-us\/how-does-naglazyme-work\/","title":{"rendered":"How does NAGLAZYME work?"},"content":{"rendered":"
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How does NAGLAZYME\u00ae<\/sup> (galsulfase) work?<\/h1>\n

NAGLAZYME\u00ae<\/sup> (galsulfase) is a kind of treatment called enzyme replacement therapy, or ERT.1<\/sup><\/h2>\n

ERT is a type of treatment for diseases that are caused by a specific enzyme deficiency. In ERT, the enzyme that is missing is replaced with a recombinant version of the missing enzyme. NAGLAZYME is a protein that is identical to the natural enzyme that is missing in MPS VI. NAGLAZYME reduces the GAG buildup that leads to MPS VI.1<\/sup><\/p>\n

In clinical studies, NAGLAZYME has been shown to help with\u00a0endurance<\/a>, which is a measure of how well your body can perform physicially. People who took NAGLAZYME were able to do better on\u00a0stair-climbing<\/a>\u00a0and\u00a0walking tests<\/a>. Additional long-term studies demonstrated that benefits continued for patients who remained on NAGLAZYME treatment.2,3<\/sup><\/p>\n

How you receive NAGLAZYME<\/h2>\n

NAGLAZYME is given by infusion. This means that once a week, you will go to a hospital or infusion center. For some people, getting infusions at home may also be an option. During your infusion, a doctor or nurse will administer NAGLAZYME to you through an intravenous (IV) line. The procedure usually lasts about 4 hours. The IV provides the enzyme directly into your bloodstream. The blood carries it to your body\u2019s cells and organs to break down GAGs within lysosomes.1<\/sup><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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References:<\/strong>\n<\/h4>\n\t\t\t\t\t\t
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  1. NAGLAZYME [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2024.\n<\/span><\/li>\n
  2. Harmatz P, Giugliani R, D Schwartz IV, et al. Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase. Mol Genet Metab<\/em>. 2008;94(4):469-475.\n<\/span><\/li>\n
  3. Giugliani R, Lampe C, Guffon N, et al. Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome)\u201410-year follow-up of patients who previously participated in an MPS VI Survey Study. Am J Med Genet A.<\/em> 2014;164A(8):1953-1964.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n
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