{"id":33,"date":"2024-11-18T12:15:09","date_gmt":"2024-11-18T12:15:09","guid":{"rendered":"https:\/\/www.naglazyme.com\/en-us\/?page_id=33"},"modified":"2026-06-03T09:52:20","modified_gmt":"2026-06-03T09:52:20","slug":"how-is-mps-vi-diagnosed","status":"publish","type":"page","link":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/","title":{"rendered":"How is MPS VI diagnosed?"},"content":{"rendered":"
\n
\n
\n \n
\n

How is MPS VI diagnosed?<\/h1>\n

 <\/p>\n

Signs and symptoms<\/h2>\n

Diagnosis of MPS VI usually starts when the doctor notices a patient has some puzzling\u00a0symptoms<\/a>. For instance, it\u2019s unusual for a child to have cloudy corneas, an enlarged liver, or stiff joints\u2014some of the problems that MPS VI may cause. Or a child may have an unusual group of more common problems\u2014such as frequent ear infections, short stature, trouble breathing, and an umbilical hernia.1<\/sup><\/p>\n

Learn more about MPS VI<\/a><\/h4>\n

The doctor may see one or two symptoms as individual problems. It\u2019s only when more and more different symptoms occur that the doctor starts to suspect one thing may be causing all of them. Even then, it may take the doctor a while to target MPS VI, because the disease is so rare.1<\/sup><\/p>\n

See a list of common symptoms<\/a><\/h4>\n

 <\/p>\n

Referral and testing<\/h2>\n

Once the doctor suspects MPS VI, he or she will refer the patient to genetics professional. The specialist will talk with the family and perform tests. The most important diagnostic test is called an \u201cenzyme assay.\u201d It measures the amount of an enzyme (called ASB) in a person\u2019s blood cells. The enzyme assay confirms an MPS VI diagnosis.2<\/sup><\/p>\n

Beginning therapy immediately after diagnosis is important<\/h2>\n

NAGLAZYME\u00ae<\/sup> (galsulfase) provides the enzyme the body needs to break down and get rid of GAGs. In timed tests, people who took NAGLAZYME were able to climb more stairs and walk farther than before.3<\/sup><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

\n
\n\t\t
\n\t\t \t\t\t

References:<\/strong>\n<\/h4>\n\t\t\t\t\t\t
    \n
  1. Wilcox WR. Lysosomal storage disorders: the need for better pediatric recognition and comprehensive care. J Pediatr.<\/em> 2004;144(suppl 5):S3-S14.\n<\/span><\/li>\n
  2. Akyol MU, Alden TD, Amartino H, et al. Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance. Orphanet J Rare Dis.<\/em> 2019;14:118.\n<\/span><\/li>\n
  3. NAGLAZYME [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2024.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n
    \n
    \n
    \n \n
    \n

    NEXT PAGE ><\/strong><\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-33","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nHow is MPS VI Diagnosed | Patient<\/title>\n<meta name=\"description\" content=\"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How is MPS VI Diagnosed | Patient\" \/>\n<meta property=\"og:description\" content=\"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin Naglazyme Patient EN-US\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-03T09:52:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/how-is-mps-vi-diagnosed\\\/\",\"url\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/how-is-mps-vi-diagnosed\\\/\",\"name\":\"How is MPS VI Diagnosed | Patient\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/#website\"},\"datePublished\":\"2024-11-18T12:15:09+00:00\",\"dateModified\":\"2026-06-03T09:52:20+00:00\",\"description\":\"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/how-is-mps-vi-diagnosed\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/how-is-mps-vi-diagnosed\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/how-is-mps-vi-diagnosed\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"How is MPS VI diagnosed?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/#website\",\"url\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/\",\"name\":\"BioMarin Naglazyme Patient EN-US\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.naglazyme.com\\\/en-us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"How is MPS VI Diagnosed | Patient","description":"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/","og_locale":"en_US","og_type":"article","og_title":"How is MPS VI Diagnosed | Patient","og_description":"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.","og_url":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/","og_site_name":"BioMarin Naglazyme Patient EN-US","article_modified_time":"2026-06-03T09:52:20+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/","url":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/","name":"How is MPS VI Diagnosed | Patient","isPartOf":{"@id":"https:\/\/www.naglazyme.com\/en-us\/#website"},"datePublished":"2024-11-18T12:15:09+00:00","dateModified":"2026-06-03T09:52:20+00:00","description":"Diagnosis of MPS VI is usually made when the doctor notices a patient has some distinctive symptoms.","breadcrumb":{"@id":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.naglazyme.com\/en-us\/how-is-mps-vi-diagnosed\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.naglazyme.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"How is MPS VI diagnosed?"}]},{"@type":"WebSite","@id":"https:\/\/www.naglazyme.com\/en-us\/#website","url":"https:\/\/www.naglazyme.com\/en-us\/","name":"BioMarin Naglazyme Patient EN-US","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.naglazyme.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":28,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":1044,"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/pages\/33\/revisions\/1044"}],"wp:attachment":[{"href":"https:\/\/www.naglazyme.com\/en-us\/wp-json\/wp\/v2\/media?parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}