How does NAGLAZYME® (galsulfase) work?
NAGLAZYME® (galsulfase) is a kind of treatment called enzyme replacement therapy, or ERT. ERT is a type of treatment for diseases that are caused by an enzyme that the body cannot make sufficiently. In ERT, the enzyme that is missing is replaced with a substitute enzyme. NAGLAZYME is a protein that is identical to the natural enzyme that is missing in MPS VI. NAGLAZYME reduces the GAG buildup that leads to MPS VI.
In clinical studies, NAGLAZYME has been shown to help with endurance, which is a measure of how well your body can perform physicially. People who took NAGLAZYME were able to do better on stair-climbing and walking tests. Additional long-term studies demonstrated that benefits continued for patients who stayed on NAGLAZYME treatment.
How you take NAGLAZYME
NAGLAZYME is given by infusion. This means that once a week, you will go to a hospital or infusion center. For some people, getting infusions at home may also be an option. During your infusion, a doctor or nurse will give you NAGLAZYME through an intravenous (IV) line. The procedure usually lasts about 4 hours. The IV gets the enzyme right into your bloodstream. The blood carries it to your body’s cells and organs to break down GAG.
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