MPS VI: A Rare but Serious Disease

About Maroteaux-Lamy Syndrome (MPS VI)

MPS VI is a rare but serious genetic disease. Only about 1100 people in the world are thought to have it.² People born with MPS VI tend to have a cluster of symptoms that may include:

Short stature
Coarse facial features
Stiff joints
Breathing problems
Other medical problems²

The name “Maroteaux-Lamy” comes from the doctors who first described the disease in 1963. The other name of the disease, “MPS VI,” stands for the medical name of the disease, “mucopolysaccharidosis VI.”²

MPS VI is a kind of disease called a “lysosomal storage disorder” or LSD. There are more than 40 known LSDs. In all of these diseases, the lack of specific enzymes causes waste to build up inside cells.³

MPS VI is an inherited condition. A child who gets one MPS VI gene from each parent will have the disease. There are different degrees of MPS VI. Some people have clear symptoms very early that grow worse quickly. Doctors call this “rapidly progressing” MPS VI. Some people may not show signs until later and have symptoms that get worse more slowly. This is called “slowly progressing” MPS VI.²

In all patients who have MPS VI, the problem and the symptoms worsen over time.²

NAGLAZYME^® (galsulfase) replaces the natural enzyme that is missing in MPS VI. In timed tests, people who took NAGLAZYME were able to climb more stairs and walk farther than before.¹