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What does MPS VI do?

MPS VI can have many different effects.

Common symptoms of MPS VI2-6

Common symptoms of MPS VI

MPS VI affects people differently. Not everyone shows all these symptoms. Some people have obvious symptoms almost from birth. Others may only notice problems over many years. Either way, as GAG builds up in the cells, MPS VI causes serious disabilities over time.2

In clinical studies, NAGLAZYME® (galsulfase) has been shown to help with endurance. In timed tests, people who took NAGLAZYME were able to climb more stairs and walk farther than before.1

 Next: “Fast progressing” vs “slow progressing” MPS VI

References

  1. NAGLAZYME [Prescribing Information]. Novato, CA: Biomarin; 2005.
  1. Giugliani R, Harmatz P, Wraith JE. Management guidelines for mucopolysaccharidosis VI. Pediatrics. 2007;120:405-418.
  1. Wilcox WR. Lysosomal storage disorders: the need for better pediatric recognition and comprehensive care. J Pediatr. 2004;144(5 Suppl):S3–S14.
  1. Swiedler SJ, Beck M, Bajbouj M, et al. Threshold effect of urinary glycosaminoglycans and the walk test as indicators of disease progression in a survey of subjects with Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). Am J Med Genet A. 2005;134:144–150.
  1. Neufeld EF, Muenzer J. The mucopolysaccharidoses. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. Vol 3. New York, NY: McGraw-Hill; 2001:3421–3452. vol.
  1. Smith KS, Hallett KB, Hall RK, Wardrop RW, Firth N. Mucopolysaccharidosis: MPS VI and associated delayed tooth eruption. Int J Oral Maxillofac Surg. 1995;24:176–180.