Charting a new course NAGLAZYME® (galsulfase) is the first treatment for MPS VI that addresses the deficiency of enzyme activity rather than just the symptoms. In MPS VI, the body is lacking in an essential enzyme needed to break down GAG, a substance that builds up inside the body, leading to MPS VI symptoms (see MPS VI is a lysosomal storage disorder). Treatment with NAGLAZYME provides people with a highly purified protein that is identical to the naturally occurring form of that enzyme. By providing sufficient quantities of this enzyme, NAGLAZYME reduces the GAG accumulation that leads to MPS VI symptoms. NAGLAZYME helps people go farther In clinical studies, NAGLAZYME has been shown to improve endurance. People with MPS VI who were treated with NAGLAZYME could walk farther and climb more stairs. How NAGLAZYME is administered NAGLAZYME is given by intravenous (IV) infusion, meaning that the medication is delivered directly into your bloodstream, and from there to your body’s cells and organs to break down the GAG buildup. NAGLAZYME is administered by a physician at a hospital or infusion center. It can only work if you stick with it MPS VI is a lifelong disease. Regular replacement of the missing ASB enzyme with NAGLAZYME helps keep NAGLAZYME working in your body. For NAGLAZYME to work best, you should try not to miss your weekly infusions. Every week an infusion is missed GAG can build up. To help make your infusion experience more enjoyable, consider making a fun ritual out of it. Bring a book, a video game, or your favorite DVD. Your weekly infusion may help you significantly. All you have to do is show up! It is important to understand that results vary and some improvements occur over a long period of time. In the clinical study, improvements were measured over a 6-month period. Start treatment today If you have MPS VI, NAGLAZYME may improve your endurance. As the only disease-focused therapy for MPS VI, NAGLAZYME is an essential part of any treatment plan. Click here for answers to frequently asked questions about NAGLAZYME. Talk to your doctor today. Printer-friendly version. Click here to download Adobe Acrobat Reader